Born in Yixing City, Jiangsu Province, China in 1977. He majored in computer graphic design and graduated from the Nanjing Arts Institute in 2000. He studied Interior and Industrial Design at the Postgraduate Department at the Design Academy Eindhoven, The Netherlands, in 2005 and received his MFA from the Interactive Media and Environment Department at the Frank Mohr Institute at Hanze University, The Netherlands in 2006. His exposure to Dutch artists of the Zero (art) and De Stijl movements and the museums while studying in The Netherlands influenced the visual aesthetic one can observe in his work today.

In 2009 he was introduced to the founder of ART LABOR Gallery, Shanghai, China and participated in two group shows with the gallery in 2010, including the "2nd Impressions" exhibition for the opening of their 2nd gallery space, featuring noted international artists such as Mustafa Hulusi, Mark Titchner and Suitman. He was also invited to participate in the 2nd Moscow International Biennale for Young Art by the respected Stella Art Foundation. These exhibitions were some of the first public exposures of his CITY DNA painting series.

Lu Xinjian's most well known series, City DNA, is "based on aerial photos sourced from Google Earth software." The artist "creates abstract paintings of major cities across the world in his series City DNA. What appears to be a mass of abstract shapes and colors, soon becomes a coherent view of the subject city, allowing the city's nuances and unique characteristics to shine through," states Juxtapoz. This series was first shown at ART LABOR Gallery, Shanghai in 2010, followed by Fabien Fryns Fine Art in Beijing and Los Angeles. Some pieces are in the White Rabbit Collection. One of his earlier and larger works, City DNA Shanghai No.3 (200x400cm) is in the DSL Collection.

In 2006 he won the Chaumont Studio Prize at the International Poster Festival in Chaumount, France. His works have been written about widely in Artforum (2011), DesignBoom, Beautiful Decay, Flavorwire, and Zilla Mag.

His work is presently on view in a solo exhibition "CITY DNA IV" at Hua Gallery, in London, England until October 2014. Lu Xinjian will launch a new series of paintings, "CITY STREAM" at ART LABOR Gallery, Shanghai, September 6, 2014. His latest artwork about living in Shanghai has been featured in Design Boom.

He currently lives and works in Shanghai.